Department of Public Health Sciences

Application of the log-linear and logistic regression models in the prediction of systemic lupus erythematosus in the dog

Kass, P. H., T. B. Farver, D. R. Strombeck and A. A. Ardans

Am J Vet Res. 1985. 46(11):2340-2345.

This study sought to mathematically define canine systemic lupus erythematosus (SLE) by unifying diagnostic criteria proposed by others. Thirty-one cases of canine SLE were selected for modeling when 4 different published schemes agreed on the diagnosis, and 122 controls were selected when a patient's status met no scheme's criteria. The log- linear method showed an association between SLE and polyarthritis, hematologic abnormalities, renal damage, dermatologic disorders, and antinuclear antibody test response (positive). Logistic regression was then used to derive a predictive algorithm that could identify cases and controls with which all published criteria would be in accordance. The final equation correctly classified 93.5% of the affected dogs and 98.4% of the controls. It was concluded that the log-linear and logistic regression models are useful for the diagnosis of clinically similar, but distinguishable, disease states.

Keywords: Animal, Dog Diseases/*diagnosis, Dogs, Lupus Erythematosus, Systemic/diagnosis/*veterinary, Models, Biological, Regression Analysis

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