Department of Public Health Sciences

Oral glutamine supplementation decreases resting energy expenditure in children and adolescents with sickle cell anemia

Williams R, Olivi S, Li CS, Storm M, Cremer L, Mackert P, Wang W

Journal of Pediatric Hematology/Oncology. 2004. 26(10):619-25.

OBJECTIVES: To determine the effects of orally administered glutamine on the resting energy expenditure (REE) and nutritional status of children and adolescents with sickle cell anemia. METHODS: Twenty-seven children and adolescents (13 boys, 14 girls), 5.2 to 17.9 years old (median 11.0 years), received orally administered glutamine (600 mg/kg per day) for 24 weeks. Measures of REE and other nutritional parameters were compared at baseline and 24 weeks. RESULTS: After 24 weeks, the patients' median REE (kcal/d) decreased by 6% (P = 0.053) as indicated by the Harris Benedict equations and by 5% (P = 0.049) as indicated by the modified equations. Patients with less than 90% ideal body weight had even greater declines in REE after 24 weeks (P

Keywords: amino acids, glutamine, sickle cell anemia, sickle cell disease, nutrition

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