Department of Public Health Sciences
|Oral glutamine supplementation decreases resting energy expenditure in children and adolescents with sickle cell anemia
Williams R, Olivi S, Li CS, Storm M, Cremer L, Mackert P, Wang W
Journal of Pediatric Hematology/Oncology. 2004. 26(10):619-25.
To determine the effects of orally administered glutamine on the resting energy expenditure (REE) and nutritional status of children and adolescents with sickle cell anemia.
Twenty-seven children and adolescents (13 boys, 14 girls), 5.2 to 17.9 years old (median 11.0 years), received orally administered glutamine (600 mg/kg per day) for 24 weeks. Measures of REE and other nutritional parameters were compared at baseline and 24 weeks.
After 24 weeks, the patients' median REE (kcal/d) decreased by 6% (P = 0.053) as indicated by the Harris Benedict equations and by 5% (P = 0.049) as indicated by the modified equations. Patients with less than 90% ideal body weight had even greater declines in REE after 24 weeks (P
Keywords: amino acids, glutamine, sickle cell anemia, sickle cell disease, nutrition
UC Davis Health System is pleased to provide this information for
general reference purposes only. It should not be considered as
a substitute for professional medical advice. You are urged to consult
with your health care provider for diagnosis of and treatment for
any health-related condition. The information provided herein may
not and should not be used for diagnosis and treatment.
Reproduction of material on this web site is hereby granted solely
for personal use. No other use of this material is authorized without
prior written approval of UC Regents.