Department of Public Health Sciences

Chronic transfusion therapy for children with sickle cell disease and recurrent acute chest syndrome

Hankins J, Jeng M, Harris S, Li CS, Liu T, Wang W

Journal of Pediatric Hematology/Oncology. 2005. 27(3):158-61.

The objective was to study the effects of chronic transfusion therapy (CTX) on the prevention of new episodes of acute chest syndrome (ACS) in children with sickle cell disease (SCD) and recurrent or unusually severe ACS. A retrospective chart review was performed of patients given CTX for recurrent or severe ACS. Frequency, median severity score, and median hospital stay for ACS episodes were determined. Differences in these values before and during CTX were analyzed. Twenty-seven patients were identified. Before treatment, the ACS incidence was 1.3 episodes per patient-year; during treatment, it decreased to 0.1 episodes per patient-year (P



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