Department of Public Health Sciences

Normal range of human red blood cell acetylcholinesterase activity

Arrieta DE, McCurdy SA, Henderson JD, Lefkowitz LJ, Reitstetter R, Wilson BW

Drug and Chemical Toxicology. 2009. 32(3):182-185.

The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel’s method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18–76) years. RBC-AChE (mean ± SD) was 0.74 ± 0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope +0.0008 delta pH units/hour for each year; P

Keywords: Acetylcholinesterase; human; red blood cell

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