Department of Public Health Sciences

Reproducibility of macular thickness measurement among five OCT instruments: effects of image resolution, image registration, and eye tracking

Chin EK, Sedeek RW, Li Y, Beckett L, Redenbo E, Chandra K, Park SS.

Ophthalmic Surgery Lasers and Imaging. 2012. 43(2):97-108.

BACKGROUND AND OBJECTIVE: To study the effect of image resolution, eye tracking, and image registration on central macular thickness reproducibility (rCMT) among spectral-domain and time-domain optical coherence tomography (SD-OCT and TD-OCT) instruments. PATIENTS AND METHODS: Seventy-six eyes were imaged (44 normal, 32 maculopathy) either twice using four SD-OCT and one TD-OCT devices or three times using Spectralis SD-OCT (with and without eye tracking) (Heidelberg Engineering, Inc., Heidelberg, Germany). Cirrus images (Carl Zeiss Meditec, Dublin, CA) were further analyzed with three-point image registration. RESULTS: All instruments had superior rCMT in normal versus pathologic eyes (P



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