Department of Public Health Sciences

Diana L Miglioretti

  Dean's Professor in Biostatistics, PhD
  Division of Biostatistics
  530-752-7168
  dmiglioretti@ucdavis.edu
  Dr. Miglioretti's CV
Multilevel and latent variable models, longitudinal and clustered data analysis, and the evaluation of screening and diagnostic tests. Collaborative research includes breast cancer screening and radiation exposure from medical imaging.

Education
2000: PhD, Biostatistics, Johns Hopkins University School of Public Health 
1996: ScM, Biostatistics, Johns Hopkins University School of Public Health 
1992: BS, Zoology, University of Maryland at College Park 

Courses Taught
BST series-SPH 298:  In 2016 & 2017: Biostatistics 290, 299, 299 D, EPI 299 Taught & Lectures given on Cancer Screening
RSNA-Cli. Trail:  2017-2019: Co-Director, Clinical Trails Methodology - RSNA: Radiological Society of North America

Professional Affiliations/Awards
2017: UC Davis School of Medicine Research Award, UC Davis
2016: North American Primary Care Research Group (NAPCRG) Pearl Award. The Pearls are chosen each year, as the top research studies presented at the Annual Meeting that will impact clinical practice.
2014: Herbert M. Stauffer Award for Best Clinical Paper., Academic Radiology
2013: Top 10 Aunt Minnie stories for 2013 (#7): JAMA Pediatrics: CT scans put children at higher cancer risk
2013: Minnies 2013 semifinalist (one of 15) for the "Most Influential Radiology Researcher"
2013: Minnies 2013 runner-up for Scientific Paper of the Year, JAMA Pediatrics
2013: One of the top 10 publications in 2013 funded by NCI’s Epidemiology and Genomics Research Program, JANMA Pediatrics
2003-2007: National Institutes of Health Clinical Research Loan Repayment Program
2002: International Biometrics Conference Travel Award for Young Investigators
2000: Margaret Merrell Award for Excellence in Research, Johns Hopkins University SPH
2000: Delta Omega, National Public Health Honorary Society
1997: International Biometric Society’s ENAR Student Travel Award
1996-2000: NIH Traineeship on the Epidemiology and Biostatistics of Aging
1994-1996: Biostatistics Departmental Scholarship, Johns Hopkins University SPH
1991: NSF Research Experience for Undergraduates Program in Neurobiology and Ecology
1991: Phi Kappa Phi Honor Society
1991: Senior Summer Scholarship Recipient, University of Maryland at College Park
1990: Golden Key National Honor Society

Significant Contributions
  1. Diane Miglioretti:. (2017). Diane Miglioretti, a sought-after biostatistics researcher, whose initiatives on breast cancer screening and radiation exposure bring out an impeccable PI to national recognition level with over $60 million dollars in collaboration research. As an outstanding educator, Dr. Miglioretti continues to deliver exceptional medical imaging applications and strive to lead future researchers, through her vigorous teaching and statistical methodology development.

  2. Miglioretti DL, Lang J, van den Broek JJ, Lee CI, van Ravesteyn N, Ritley D, Kerlikowske K, Fenton JJ, Melnikow J, de Koning HJ, Hubbard RA. (2016). Radiation-Induced Breast Cancer Incidence and Mortality from Digital Mammography Screening: A Modeling Study. Ann Intern Med

  3. Miglioretti DL, Zhu W, Kerlikowske K, Sprague BL, Onega T, Buist DSM, Henderson LM, Smith RA - Breast Cancer Surveillance Consortium. (2015). Breast Tumor Prognostic Characteristics and Biennial vs Annual Mammography, Age, and Menopausal Status. JAMA Oncol, 1(8):1069-77.

  4. Miglioretti DL, Ichikawa L, Smith RA, Bassett LW, Feig SA, Monsees B, Parikh JR, Rosenberg RD, Sickles EA, Carney PA. (2015). Criteria for identifying radiologists with acceptable screening mammography interpretive performance on basis of multiple performance measures. AJR Am J Roentgenol, 204(4):W486-91.

  5. Miglioretti DL, Zhang Y, Johnson E, Lee C, Morin RL, Vanneman N, Smith-Bindman R. (2014). Personalized technologist dose audit feedback for reducing patient radiation exposure from CT. J Am Coll Radiol, 11(3):300-8.

  6. Miglioretti DL, Johnson E, Williams A, Greenlee RT, Weinmann S, Solberg LI, Feigelson HS, Roblin D, Flynn MJ, Vanneman N, Smith-Bindman R. (2013). The use of computed tomography in pediatrics and the associated radiation exposure and estimated cancer risk. JAMA Pediatr, 167(8):700-7.

  7. Miglioretti DL, McCulloch C, Zeger SL. . (2009). “Combining images across multiple subjects: a study of direct cortical electrical interference.” . J Am Stat Assoc. , 97(457):125-35.

  8. Miglioretti DL, Haneuse SJ, Anderson ML. (2009). Statistical approaches for modeling radiologists’ interpretive performance. Acad Radiol, 16(2):227-38.

  9. Miglioretti DL, Gard CC, Carney PA, Onega TL, Buist DSM, Sickles EA, Kerlikowske K, Rosenberg RD, Yankaskas BC, Geller BM, Elmore JG. (2009). When radiologists perform best: the learning curve in screening mammography interpretation. Radiology, 253(3):632-40.

  10. Miglioretti DL, Brown ER. (2008). A marginalized diffusion model for estimating age at first lower endoscopy use from current-status data. J R Stat Soc Ser C Appl Stat, 57(1):61-74.

  11. Miglioretti DL, Heagerty PJ. (2007). Marginal modeling of nonnested multilevel data using standard software. Am J Epidemiol, 165(4):453-63.

  12. Miglioretti DL, Smith-Bindman R, Abraham L, Brenner RJ, Carney PA, Bowles EJ, Buist DS, Elmore JG. (2007). Radiologist characteristics associated with interpretive performance of diagnostic mammography. J Natl Cancer Inst, 99(24):1854-63.

  13. Miglioretti DL, Rutter CM, Geller BM, Cutter G, Barlow WE, Rosenberg R, Weaver DL, Taplin SH, Ballard-Barbash R, Carney PA, Yankaskas BC, Kerlikowske K. (2004). Effect of breast augmentation on the accuracy of mammography and cancer characteristics. JAMA, 291(4):442-50.

  14. Miglioretti DL, Heagerty PJ. (2004). Marginal modeling of multilevel binary data with time-varying covariates. Biostatistics, 5(3):381-98.

  15. Miglioretti DL. (2003). “Latent transition regression for mixed outcomes.”. Biometrics, 59(3):710-20.

  16. Miglioretti DL, McCulloch C, Zeger SL. . (2000). “Template mixture models for Direct Cortical Electrical Interference Data.”. Biostatistics, 1(4):403-21.


Selected Publications
  1. Trentham-Dietz A, Kerlikowske K, Stout NK, Miglioretti DL, Schechter CB, Ergun MA, van den Broek JJ, Alagoz O, Sprague BL, van Ravesteyn NT, Near AM, Gangnon RE, Hampton JM, Chandler Y, de Koning HJ, Mandelblatt JS, Tosteson AN. (2016). Breast Cancer Surveillance Consortium and Cancer Intervention and Surveillance Modeling Network. “Tailoring Breast Cancer Screening Intervals by Breast Density and Risk for Women Aged 50 Years or Older: Collaborative Modeling of Screening Outcomes. Annuals of Internal Medicine, Epub ahead of print

  2. Mandelblatt JS, Stout NK, Schechter CB, van den Broek JJ, Miglioretti DL, Krapcho M, Trentham-Dietz A, Munoz D, Lee SJ, Berry DA, van Ravesteyn NT, Alagoz O, Kerlikowske K, Tosteson AN, Near AM, Hoeffken A, Chang Y, Heijnsdijk EA, Chisholm G, Huang X, Huang H, Ergun MA, Gangnon R, Sprague BL, Plevritis S, Feuer E, de Koning HJ, Cronin KA. . (2016). Collaborative Modeling of the Benefits and Harms Associated With Different U.S. Breast Cancer Screening Strategies. Annuals of Internal Medicine, 164(4):215-25.

  3. Melnikow J, Xing G, Cox G, Leigh P, Mills L, Miglioretti DL, Moghadassi M, Smith-Bindman R. . (2016). Cost Analysis of the STONE Trial: Can Healthcare Costs be Reduced One Test at a Time? Medical Care, 54(4):337-42.

  4. Ahern TP, Sprague BL, Bissell M, Miglioretti DL, Buist DSM, Braithwaite D, Kerlikowske K. (2016). Family history of breast cancer, breast density, and breast cancer risk in a U.S. breast cancer screening population. Cancer Epidemiology, Biomarkers & Prevention, Provisionally Accepted

  5. Sprague BL, Arao R, Miglioretti DL, Henderson LM, Buist DSM, Onega T, Rauscher GH, Lee JM, Tosteson ANA, Kerlikowske K, Lehman CD. (2016). National Performance Benchmarks for Modern Diagnostic Digital Mammography: Update from the Breast Cancer Surveillance Consortium. Radiology, In Press

  6. Lehman CD, Arao R, Sprague BL, Lee JM , Buist DSM, Kerlikowske K, Henderson LM, Onega T, Tosteson ANA, Rauscher GH, Miglioretti DL. (2016). National Performance Benchmarks for Modern Screening Digital Mammography: Update from the Breast Cancer Surveillance Consortium. Radiology, Epub ahead of print

  7. Lee JM, Ichikawa L, Valencia E, Miglioretti DL, Wernli K, Buist DSM, Kerlikowske K, Henderson LM, Sprague BL, Onega T, Rauscher GH, Lehman CD. (2016). Performance benchmarks for screening breast MRI in community practice. Radiology, Provisionally Accepted

  8. Engmann NJ, Golmakani MK, Miglioretti DL, Sprague BL, Kerlikowske K. (2016). Population Attributable Risk Proportion of Clinical Risk Factors for Breast Cancer. JAMA Oncology , In Press

  9. Marcus PM, Pashayan N, Church TR, Doria-Rose VP, Gould MK, Hubbard RA, Marrone M, Miglioretti DL, Pharoah PD, Pinsky PF, Rendle KA, Robbins HA, Roberts MC, Rolland B, Schiffman M, Tiro JA, Zauber AG, Winn DM, Khoury MJ. . (2016). Population-based precision cancer screening: a symposium on evidence, epidemiology, and next steps. Cancer Epidemiology, Biomarkers & Prevention, 25(11):1449-1455.

  10. Smith-Bindman R, Wang Y, Yellen-Nelson TR, Moghadassi M, Wilson N, Gould R, Seibert A, Boone JM, Krishnam M, Lamba R, Hall DJ, Miglioretti DL. (2016). Predictors of CT Radiation Dose and Their Effect on Patient Care: A Comprehensive Analysis Using Automated Data. Radiology, Epub ahead of print

  11. Elmore JG, Cook AJ, Bogart A, Carney PA, Geller BM, Taplin SH, Buist DS, Onega T, Lee CI, Miglioretti DL. (2016). Radiologists' interpretive skills in screening vs. diagnostic mammography: are they related? Clinical Imaging, 40(1):1096-1103.

  12. Sherman ME, Ichikawa L, Pfeiffer RM, Miglioretti DL, Kerlikowske K, Tice J, Vacek PM, Gierach GL. (2016). Relationship of Predicted Risk of Developing Invasive Breast Cancer, as Assessed with Three Models, and Breast Cancer Mortality Among Breast Cancer Patients. PLoS One, 11(8):e0160966.

  13. Kerlikowske K, Gard CC, Tice J, Ziv E, Cummings S, Miglioretti DL. (2016). Risk Factors that Increase Risk of Estrogen Receptor Positive and Negative Breast Cancer. Journal of National Cancer Institute, In Press

  14. Hubbard RA, Ripping TM, Chubak J, Broeders MJ, Miglioretti DL. . (2016). Statistical methods for estimating the cumulative risk of screening mammography outcomes. Cancer Epidemiology, Biomarkers & Prevention, 25(3):513-20.

  15. Menes TS, Kerlikowske K, Lange J, Jaffer S, Rosenberg R, Miglioretti DL. . (2016). Subsequent breast cancer risk following diagnosis of atypical ductal hyperplasia on needle biopsy. JAMA Oncology , Epud ahead of print

  16. Melnikov J, Fenton JJ, Whitlock EP, Miglioretti DL, Weyrich MS, Thomposon JH, Shah K. . (2016). Supplemental Screening for Breast Cancer in Women with Dense Breasts: A Systematic Review for the U.S. Preventive Services Task Force. Annuals of Internal Medicine, 164(4):268-78.

  17. Henderson LM, Miglioretti DL, Kerlikowske K, Wernli KJ, Sprague BL, Lehman CM. (2015). Breast cancer characteristics associated with digital versus screen-film mammography for screen-detected and interval cancers. American journal of roentgenology, 205(3):676-684.

  18. Tice J, Miglioretti DL, Li C, Vachon C, Gard C, Kerlikowske K. (2015). Breast density and benign breast disease: Risk assessment to identify women at high risk of breast cancer. Journal of Clinical Oncology, 33(28):3137-43.

  19. Miglioretti DL, Zhu W, Kerlikowske K, Sprague BL, Onega T, Buist DSM, Henderson LM, Smith RA. (2015). Breast Tumor Prognostic Characteristics and Biennial vs Annual Mammography, Age, and Menopausal Status. JAMA Oncology, (in Press)

  20. Bahadori A, Miglioretti D, Kruger R, Flynn M, Weinmann S, Smith-Bindman R, Lee C. (2015). Calculation of organ doses for a large number of patients undergoing CT examinations. American journal of roentgenology, 205(4):827-33.

  21. Smith-Bindman R, Moghadassi M, Griffey R, Mayo-Smith W, Miglioretti DL. (2015). Computed Tomography Radiation Dose in Patients with Suspected Urolithiasis. JAMA Internal Medicine, 175(8):1413-6.

  22. Miglioretti DL, Ichikawa L, Smith RA, Bassett LW, Feig SA, Monsees B, Parikh JR, Rosenberg RD, Sickles EA, Carney PA. (2015). Criteria for identifying radiologists with acceptable screening mammography interpretive performance on basis of multiple performance measures. American journal of roentgenology, 204(4):W486-91.

  23. Lehman C, Wellman RD, Buist DSM, Kerlikowske K, Tosteson ANA, Miglioretti DL. (2015). Diagnostic Accuracy of Digital Screening Mammography With and Without Computer-Aided Detection. JAMA Internal Medicine., (in Press)

  24. Onega T, Goldman L, Walker RL, Miglioretti DL, Buist DSM, Taplin T, Geller BM, Hill DA, Smith-Bindman R. (2015). Facility Mammography Volume in Relation to Breast Cancer Screening Outcomes. Journal of Medical Screening, [Epub ahead of print]

  25. Nelson HD, O’Meara ES, Kerlikowske K, Balch S, Miglioretti DL. . (2015). Factors affecting the rates and consequences of false positive and false negative digital mammography screening exams: An analysis of registry data. Annals of Internal Medicine, (in Press)

  26. Kerlikowske K, Zhu W, Tosteson ANA, Sprague BL, Tice JA, Lehman C, Miglioretti DL. (2015). Identifying Women with Dense Breasts at High Risk of Interval Cancers. Annals of Internal Medicine, 162(10):673-8.

  27. Gard CC, Bowles EJA, Miglioretti DL, Taplin SH, Rutter CM. (2015). Misclassification of Breast Imaging Reporting and Data System (BI-RADS) mammographic density and implications for breast density reporting legislation. The Breast Journal, 21(5):481-9.

  28. Kerlikowske K, Gard CC, Sprague BL, Tice JA, Miglioretti DL. (2015). One vs. Two Breast Density Measures to Predict 5- and 10- Year Breast Cancer Risk. Cancer Epidemiology, Biomarkers & Prevention, 24(6):889-97.

  29. Jackson SL, Abraham L, Miglioretti DL, Buist DS, Kerlikowske K, Onega T, Carney PA, Sickles EA, Elmore JG. (2015). Patient and Radiologist Characteristics Associated With Accuracy of Two Types of Diagnostic Mammograms. American journal of roentgenology, 205(2):456-63.

  30. Smith-Bindman R, Moghadassi M, Wilson N, Nelson TR, Boone JM, Cagnon CH, Gould R, Hall DJ, Krishnam M, Lamba R, McNitt-Gray M, Seibert A, Miglioretti DL. (2015). Radiation Doses in Consecutive CT Examinations from Five University of California Medical Centers. Radiology, 277(1):134-41.

  31. Miglioretti DL, Lang J, van den Broek JJ, Lee CI, van Ravesteyn N, Ritley D, Kerlikowske K, Fenton JJ, Melnikow J, de Koning HJ, Hubbard RA. (2015). Radiation-Induced Breast Cancer Incidence and Mortality from Digital Mammography Screening: A Modeling Study. Annals of Internal Medicine, (in Press)

  32. Torres-Mejía G, Smith RA, de la Luz Carranza-Flores M, Bogart A, Bogart A, Martínez-Matsushita L, Miglioretti DL, Kerlikowske K, Ortega-Olvera C, Montemayor-Varela E, Angeles-Llerenas A, Bautista-Arredondo S, Sánchez-González G, Martínez-Montañez OG, Uscanga-Sánchez SR, Lazcano-Ponce E, Hernández-Ávila M. (2015). Radiographers supporting radiologists in the interpretation of screening mammography: A viable strategy to meet the shortage in the number of radiologists. BMC Cancer, 15(1):410.

  33. Houssami N, Abraham LA, Onega T, Collins LC, Sprague BL, Hill DA, Miglioretti DL. (2014). Accuracy of screening mammography in women with a history of lobular carcinoma in situ or atypical hyperplasia of the breast. Breast Cancer Research and Treatment, 145(3):765-73.

  34. Burnside ES, Lin Y, Munoz del Rio A, Pickhardt PJ, Wu Y, Strigel RM, Elezaby MA, Kerr EA, Miglioretti DL. (2014). Addressing the challenge of assessing physician-level screening performance: Mammography as an example. PLoS ONE, 9(2):e89418.

  35. Sprague BL, Stout NK, Schechter C, van Ravesteyn NT, Cevik M, Alagoz O, Lee CI, van den Broek JJ, Miglioretti DL, Mandelblatt JS, de Koning HJ, Kerlikowske K, Lehman CD, A Tosteson AN. (2014). Benefits, Harms, and Cost-Effectiveness of Supplemental Ultrasonography Screening for Women With Dense Breasts. [Epub ahead of print]

  36. Stout NK, Lee SJ, Schechter CB, Kerlikowske K, Alagoz O, Berry D, Buist DS, Cevik M, Chisholm G, de Koning HJ, Huang H, Hubbard RA, Miglioretti DL, Munsell MF, Trentham-Dietz A, van Ravesteyn NT, Tosteson AN, Mandelblatt JS. (2014). Benefits, harms, and costs for breast cancer screening after US implementation of digital mammography. Journal of the National Cancer Institute, 106(6)

  37. Johnson JM, Johnson AK, O'Meara ES, Miglioretti DL, Geller BM, Hotaling EN, Herschorn SD. (2014). Breast Cancer Detection with Short-Interval Follow-up Compared with Return to Annual Screening in Patients with Benign Stereotactic or US-guided Breast Biopsy Results. Radiology, [Epub ahead of print]

  38. Lee CI, Ichikawa L, Rochelle MC, Kerlikowske K, Miglioretti DL, Sprague BL, DeMartini WB, Wernli KJ, Joe BN, Yankaskas BC, Lehman CD. (2014). Breast MRI BI-RADS assessments and abnormal interpretation rates by clinical indication in US community practices. Academic Radiology, 21(11):1370-6.

  39. Lee CI, Cevik M, Alagoz O, Sprague BL, Tosteson AN, Miglioretti DL, Kerlikowske K, Stout NK, Jarvik JG, Ramsey SD, Lehman CD. (2014). Comparative Effectiveness of Combined Digital Mammography and Tomosynthesis Screening for Women with Dense Breasts. Radiology, [Epub ahead of print]

  40. Geller BM, Bogart A, Carney PA, Sickles EA, Smith RA, Monsees B, Bassett LW, Buist DM, Kerlikowske K, Onega T, Yankaskas B, Haneuse S, Hill DA, Wallis M, Miglioretti DL. (2014). Educational interventions to improve screening mammography interpretation: a randomized controlled trial. American Journal of Roentgenolgy, 202(6):W586-96.

  41. Buist DS, Anderson ML, Smith RA, Carney PA, Miglioretti DL, Monsees BS, Sickles EA, Taplin SH, Geller BM, Yankaskas BC, Onega TL. (2014). Effect of radiologists' diagnostic work-up volume on interpretive performance. Radiology, 273(2):351-64.

  42. Wernli KJ, O'Meara ES, Kerlikowske K, Miglioretti DL, Muller CY, Onega T, Sprague BL, Henderson LM, Buist DS. (2014). Investigation of mammographic breast density as a risk factor for ovarian cancer. Journal of the National Cancer Institute, 106(1):doi: 10.1093/jnci/djt341.

  43. Trentham-Dietz A, Sprague BL, Hampton JH, Miglioretti DL, Nelson HD, Titus LJ, Egan KM, Remington PL, Newcomb PA. (2014). Modification of breast cancer risk according to age and menopausal status: A combined analysis of five population-based case-control studies. Breast Cancer Research and Treatment, 145(1):165-175.

  44. Miglioretti DL, Zhang Y, Johnson E, Lee C, Morin R, Vanneman N, Smith-Bindman R. (2014). Personalized technologist dose audit feedback for reducing patient radiation exposure From CT. Journal of the American College of Radiology, 11(3):300-308.

  45. Sprague BL, Gangnon RE, Burt V, Trentham-Dietz A, Hampton JM, Wellman RD, Kerlikowske K, Miglioretti DL. (2014). Prevalence of mammographically dense breasts in the United States. Journal of the National Cancer Institute, 106(10):pii: dju255.

  46. Keegan J, Miglioretti DL, Gould R, Donnelly LF, Wilson ND, Smith-Bindman R. (2014). Radiation dose metrics in CT: Assessing dose using the National Quality Forum CT Patient Safety Measure. Journal of the American College of Radiology, 11(3):309-315.

  47. Smith-Bindman R, Aubin C, Bailitz J, Bengiamin RN, Camargo CA Jr, Corbo J, Dean AJ, Goldstein RB, Griffey RT, Jay GD, Kang TL, Kriesel DR, Ma OJ, Mallin M, Manson W, Melnikow J, Miglioretti DL, Miller SK, Mills LD, Miner JR, Moghadassi M, Noble VE, Press GM, Stoller ML, Valencia VE, Wang J, Wang RC, Cummings SR. (2014). Ultrasonography versus computed tomography for suspected nephrolithiasis. The New England Journal of Medicine, 371(12):1100-10.

  48. Smith-Bindman R, Aubin C, Bailitz J, Bengiamin RN, Camargo CA Jr, Corbo J, Dean AJ, Goldstein RB, Griffey RT, Jay GD, Kang TL, Kriesel DR, Ma OJ, Mallin M, Manson W, Melnikow J, Miglioretti DL, Miller SK, Mills LD, Miner JR, Moghadassi M, Noble VE, Press GM, Stoller ML, Valencia VE, Wang J, Wang RC, Cummings SR. (2014). Ultrasonography versus computed tomography for suspected nephrolithiasis. New England Journal of Medicine, 371(12):1100-10.