Department of Public Health Sciences

Kyoungmi Kim

  Associate Professor, PhD
  Division of Biostatistics
Statistical Genetics, bioinformatics, biomarker discovery based on high-throughput -omics data

2005: Postdoctoral Fellowship, Statistical genetics and genomics, Biostatistics, University of Alabama at Birmingham 
2003: Ph.D., Statistics, University of Kentucky, Lexington, KY 
1999: M.S., Applied Mathematics, University of Kentucky, Lexington, KY 

Courses Taught
BST-252:  Advanced Topics in Biostatistics: Biomarkers and Bioinformatics
CLH-245:  Biostatistics for Biomedical Science

Selected Publications
  1. Awasthi S, Wilken R, Patel F, German JB, Mills DA, Lebrilla CB, Kim K, Freeman SL, Smilowitz JT, Armstrong AW, Maverakis E. (2016). Dietary supplementation with Bifidobacterium longum subsp. infantis (B. infantis) in healthy breastfed infants: study protocol for a randomised controlled trial. Trials, 17(1):340

  2. Ruhaak LR, Taylor SL, Stroble C, Nguyen UT, Parker EA, Song T, Lebrilla CB,Rom WN, Pass H, Kim K, Kelly K, Miyamoto S. (2016). Differential N-Glycosylation Patterns in Lung Adenocarcinoma Tissue. J Proteome Res, 14(11):4538-49

  3. Taylor SL, Ruhaak LR, Kelly K, Weiss RH, Kim K . (2016). Effects of imputation on correlation: implications for analysis of mass spectrometry data from multiple biological matrices . Brief Bioinform, pii: bbw010

  4. Taylor SL, Ruhaak LR, Weiss RH, Kelly K, Kim K . (2016). Multivariate Two-part Statistics for Analysis of Correlated Mass Spectrometry Data from Multiple Biological Specimens. Bioinformatics, pii: btw578

  5. Ruhaak LR, Kim K, Stroble C, Taylor SL, Hong Q, Miyamoto S, Lebrilla CB, Leiserowitz G. (2016). Protein-Specific Differential Glycosylation of Immunoglobulins in Serum of Ovarian Cancer Patients. J Proteome Res, 15(3):1002-10

  6. Seritan AL, Kim K, Benjamin I, Seritan I, Hagerman RJ. (2016). Risk Factors for Cognitive Impairment in Fragile X-Associated Tremor/Ataxia Syndrome. J Geriatr Psychiatry Neurol,(pii: 0891988716666379)

  7. Medici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, Su RJ, Islam MS, Keen CL, Miller AY, Rutledge JC, Halsted CH, LaSalle JM. (2016). Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model. Epigenetics, 11(11):804-818

  8. Enkhmaa B, Anuurad E, Zhang W, Kim K, Berglund L. . (2015). Diverging trajectory patterns of systemic versus vascular inflammation over age in healthy Caucasians and African-Americans. . Atherosclerosis. , 239(2):509-15

  9. Fahrmann JF, Kim K, DeFelice BC, Taylor SL, Gandara DR, Yoneda KY, Cooke DT, Fiehn O, Kelly K, Miyamoto S. (2015). Investigation of metabolomic blood biomarkers for detection of adenocarcinoma lung cancer. Cancer Epidemiol Biomarkers Prev. , 24(11):1716-23

  10. Wikoff WR, Grapov D, Fahrmann JF, DeFelice B, Rom WN, Pass HI, Kim K, Nguyen U, Taylor SL, Gandara DR, Kelly K, Fiehn O, Miyamoto S. . (2015). Metabolomic markers of altered nucleotide metabolism in early stage adenocarcinoma. Cancer Prev Res, 8(5):410-8

  11. Polage CR, Gyorke CE, Kennedy MA, Leslie JL, Chin DL, Wang S, Nguyen HH, Huang B, Tang YW, Lee LW, Kim K, Taylor S, Romano PS, Panacek EA, Goodell PB, Solnick JV, Cohen SH. (2015). Overdiagnosis of Clostridium difficile Infection in the Molecular Test Era. JAMA internal medicine, 175(11):1792-801

  12. Wilken R, Li CS, Sharon VR, Kim K, Patel FB, Patel F, Maverakis E. (2015). Topical clobetasol for the treatment of toxic epidermal necrolysis: study protocol for a randomized controlled trial. Trials, 16:374

  13. Kim K, Ruhaak LR, Nguyen UT, Taylor SL, Dimapasoc LM, Williams CC, Stroble C, Ozcan S, Miyamoto S, Lebrilla C, Leiserowitz GS. . (2014). Evaluation of Glycomic Profiling as a Diagnostic Biomarker for Epithelial Ovarian Cancer. Cancer Epidemiol Biomarkers Prev. , 23(4):611-21

  14. Kim K, Mall C, Taylor SL, Hitchcock S, Zhang C, Wettersten HI, Jones AD, Chapman A, Weiss RH. . (2014). Mealtime, temporal, and daily variability of the human urinary and plasma metabolomes in a tightly controlled environment. PLoS One, 9(1):e86223

  15. Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G. (2014). Shc depletion stimulates brown fat activity in vivo and in vitro. . Aging Cell, 13(6):1049-58

  16. Taylor SL, Leiserowitz GS, Kim K. (2013). Accounting for undetected compounds in statistical analyses of mass spectrometry 'omic studies. Stat Appl Genet Mol Biol., 12(6):703-22

  17. Ruhaak LR, Taylor SL, Miyamoto S, Kelly K, Leiserowitz GS, Gandara D, Lebrilla CB, Kim K. (2013). Chip-based nLC-TOF-MS is a highly stable technology for large-scale high-throughput analyses. Anal Bioanal Chem. , 405(14):4953-8

  18. Ruhaak LR, Nguyen UT, Stroble C, Taylor SL, Taguchi A, Hanash SM, Lebrilla CB, Kim K, Miyamoto S. (2013). Enrichment strategies in glycomics-based lung cancer biomarker development. Proteomics Clin Appl, doi: 10.1002/prca.201200131

  19. Medici V, Shibata NM, Kharbanda KK, LaSalle JM, Woods R, Liu S, Engelberg JA, Devaraj S, Török NJ, Jiang JX, Havel PJ, Lönnerdal B, Kim K, Halsted CH. (2013). Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease. . Hepatology, 57(2):555-65

  20. Gungor Z, Anuurad E, Enkhmaa B, Zhang W, Kim K, Berglund L. (2012). Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk. Atherosclerosis, 223(1):230-4.

  21. Hunsaker MR, Kim K, Willemsen R, Berman RF. (2012). CGG trinucleotide repeat length modulates neural plasticity and spatiotemporal processing in a mouse model of the fragile X premutation. Hippocampus, 22(12):2260-75.

  22. Diep AA, Hunsaker MR, Kwock R, Kim K, Willemsen R, Berman RF. (2012). Female CGG knock-in mice modeling the fragile X premutation are impaired on a skilled forelimb reaching task. Neurobiology of Learning and Memory, 97(2):229-34.

  23. Ganti S, Taylor SL, Abu Aboud O, Yang J, Evans C, Osier MV, Alexander DC, Kim K, Weiss RH. (2012). Kidney tumor biomarkers revealed by simultaneous multiple matrix metabolomics analysis. Cancer Research, 72(14):3471-9.

  24. Ganti S, Taylor SL, Kim K, Hoppel CL, Guo L, Yang J, Evans C, Weiss RH. (2012). Urinary acylcarnitines are altered in human kidney cancer. International Journal of Cancer, 130(12):2791-800.

  25. Taylor SL, Kim K. (2011). A jackknife and voting classifier approach to feature selection and classification. Cancer Informatics,(10):133-47.

  26. Anuurad E, Enkhmaa B, Gungor Z, Zhang W, Tracy RP, Pearson TA, Kim K, Berglund L. (2011). Age as a modulator of inflammatory cardiovascular risk factors. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(9):2151-6.

  27. Weiss RH, Kim K. (2011). Metabolomics in the study of kidney diseases. Nature Reviews Nephrology, 8(1):22-33.

  28. Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA. (2011). The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell, 10(1):55-65.

  29. Kim K, Taylor SL, Ganti S, Guo L, Osier MV, Weiss RH. (2011). Urine metabolomic analysis identifies potential biomarkers and pathogenic pathways in kidney cancer. A Journal of Integrative Biology, 15(5):293-303.

  30. Kim K, Zakharkin SO, Allison DB. (2010). Expectations, validity, and reality in gene expression profiling. Journal of Clinical Epidemiology, 63(9):950-9.

  31. Park SK, Kim K, Page GP, Allison DB, Weindruch R, Prolla TA. (2009). Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell, 8(4):484-495.