Department of Public Health Sciences

Laurel Beckett

  Biostatistics Division Chief, Distinguished Professor, PhD
  Division of Biostatistics
  530-754-7161
  labeckett@ucdavis.edu
Statistical methods for longitudinal data, population-based studies, and translational research between basic science and clinical medicine. Collaborative research using these methods for studies of chronic diseases, especially the relationship between biology, etiology, and treatment. Current and recent research includes work on Alzheimer's, cancer, and musculoskeletal disorders.

Education
PhD, Statistics, Stanford University
MS, Statistics, Stanford University
BA, Mathematics, Pomona College

Courses Taught
EPI-208:  Analysis and Interpretation of Epidemiologic Data
PHS-444:  Mentored Clincal Traning
STA/BST-224:  Longitudinal Data Analysis
STA/BST-225:  Clinical Trials

Professional Affiliations/Awards
Fellow, American Statistical Associaton, 2004
Outstanding Faculty Award, Graduate Group in Epidemiology, 2003
Dean's Award for Excellence in Mentoring, 2002

Selected Publications
  1. Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR Jr, Beckett LA, Donohue M, Jagust W, Schuff N, Weiner MW; on behalf of the Alzheimer’s Disease Neuroimaging Initiative. (2014). Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment. Brain, 2014 Mar 12. [Epub ahead of print]
    PMID: 24625697 [PubMed - as supplied by publisher]

  2. Healy E, Anderson S, Cui J, Backett L, Chen AM, Perks J, Stern R, Mayadev J. (2013). Skin dose effects of postmastectomy chest wall radiation therapy using brass mesh as an alternative to tissue equivalent bolus. Practical Radiation Oncology, 3(2):45-53.

  3. Norman SA, Hobbs RC, Wuertz S, Melli A, Beckett LA, Chouicha N, Kundu A, Miller WA. (2013). Fecal pathogen pollution: sources and patterns in water and sediment samples from the upper Cook Inlet, Alaska ecosystem. Environmental Science: Processes & Impacts, 1(15):1041-1051.

  4. Early DR, Widaman KF, Harvey D, Beckett L, Quitania Park L, Tomaszewski Farias S, Reed BR, Decarli C, Mungas D. (2013). Demographic Predictors of Cognitive Change in Ethnically Diverse Older Persons. Psychology and Aging, [Epub ahead of print]

  5. Cardiff RD, Hubbard NE, Engelberg JA, Munn RJ, Miller CH, Walls JE, Chen JQ, Velásquez-García HA, Galvez JJ, Bell KJ, Beckett LA, Li YJ, Borowsky AD. (2013). Quantitation of fixative-induced morphologic and antigenic variation in mouse and human breast cancers. Laboratory Investigation, 93(4):480-97.

  6. Norman SA, Beckett LA, Miller WA, St Leger J, Hobbs RC. (2013). Variation in hematologic and serum biochemical values of belugas (Delphinapterus leucas) under managed care. Journal of Zoo and Wildlife Medicine, 44(2):376-388.

  7. Nettiksimmons J, Beckett L, Schwarz C, Carmichael O, Fletcher E, Decarli C. (2013). Subgroup of ADNI normal controls characterized by atrophy and cognitive decline associated with vascular damage. Psychology and Aging, 28(1):191-201.

  8. Villablanca AC, Beckett L, Nettiksimmons J, Howell LP. (2013). Improving knowledge, awareness, and use of flexible career policies through an accelerator intervention at the University of California, Davis, School of Medicine. Academic Medicine, 88(8):771-7.

  9. Spielvogel R, Stednick Z, Beckett L, Latimore D. (2012). Sources of variability in medical student evaluations on the internal medicine clinical rotation. International Journal of Medical Education, 2012(3):245-251.

  10. Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Liu E, Morris JC, Petersen RC, Saykin AJ, Schmidt ME, Shaw L, Siuciak JA, Soares H, Toga AW, Trojanowski JQ; Alzheimer's Disease Neuroimaging Initiative. (2012). The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimer's & Dementia, 8(1):201-2.

  11. He J, Wong VS, Fletcher E, Maillard P, Lee DY, Iosif AM, Singh B, Martinez O, Roach AE, Lockhart SN, Beckett L, Mungas D, Farias ST, Carmichael O, DeCarli C. (2012). The contributions of MRI-based measures of gray matter, white matter hyperintensity, and white matter integrity to late-life cognition. American Journal of Neuroradiology, 33(9):1797-1803.

  12. Han SD, Gruhl J, Beckett L, Dodge HH, Stricker NH, Farias S, Mungas D; Alzheimer's Disease Neuroimaging Initiative. (2012). Beta amyloid, tau, neuroimaging, and cognition: sequence modeling of biomarkers for Alzheimer's Disease. Brain Imaging and Behavior, 6(4):610-20.

  13. Howell LP, Beckett LA, Nettiksimmons J, Villablanca AC. (2012). Generational and Gender Perspectives on Career Flexibility: Ensuring the Faculty Workforce of the Future. The American Journal of Medicine, 125(7):719-28.

  14. Chin EK, Sedeek RW, Li Y, Beckett L, Redenbo E, Chandra K, Park SS. (2012). Reproducibility of macular thickness measurement among five OCT instruments: effects of image resolution, image registration, and eye tracking. Ophthalmic Surgery Lasers and Imaging, 43(2):97-108.

  15. Semrad TJ, Eddings C, Pan CX, Lau DH, Gandara D, Beckett L, Lara PN Jr. (2012). Feasibility study of intra-patient sorafenib dose-escalation or re-escalation in patients with previously treated advanced solid tumors. Investigational New Drugs, 30(5):2001-7.

  16. Norman SA, Goertz CE, Burek KA, Quakenbush LT, Cornick LA, Romano TA, Spoon T, Miller W, Beckett LA, Hobbs RC. (2012). Seasonal Hematology and Serum Chemistry of Wild Beluga Whales (Delphinapterus Leucas) in Bristol Bay, Alaska. Journal of Wildlife Diseases, 1(48):21-32.

  17. Henderson PT, Li T, He M, Zhang H, Malfatti M, Gandara D, Grimminger PP, Danenberg KD, Beckett L, de Vere White RW, Turteltaub KW, Pan CX. (2011). A microdosing approach for characterizing formation and repair Publications 22 of carboplatin-DNA monoadducts and chemoresistance. International Journal of Cancer, 129(6):1425-34.

  18. Sangha R, Davies AM, Lara PN Jr, Mack PC, Beckett LA, Hesketh PJ, Lau D, Li T, Perkins N, Gandara DR. (2011). Intercalated Erlotinib- Docetaxel Dosing Schedules Designed to Achieve Pharmacodynamic Separation: Results of a Phase 1/11 Trial. Journal of Thoracic Oncology, 6(12):2112-2119.

  19. Villablanca AC,Beckett L, Nettiksimmons J, Howell LP. (2011). Career Flexibility and Family-Friendly Policies: An NIH-Funded Study to Enhance Women's Careers in Biomedical Sciences. Journal of Women's Health, 20(10):1485-1496.

  20. Meyers FJ, Carducci M, Loscalzo MJ, Linder J, Greasby T, Beckett LA. (2011). Effects of a Problem-Solving Intervention (COPE) on Quality of Life for Patients with Advanced Cancer on Clinical Trials and Their Caregivers: Simultaneous Care Education Intervention (SCEI): Linking Palliation and Clinical Trials. Journal of Palliative Medicine, 14(4):465-73.

  21. Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Thompson PM, Reiman EM, Jack CR, Fox NC, Jagust WJ, Harvey DJ, Beckett LA, Gamst A, Aisen PS, Petersen RC, Weiner MW. (2011). Impact of apolipoprotein #4-cerebrospinal fluid beta-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment. Alzheimers & Dementia, 7(5):514-20.

  22. Boyce W, Shender L, Schultz L, Vickers W, Johnson C, Ziccardi M, Beckett L, Padgett K, Crosbie P, Sykes J. (2011). Survival analysis of dogs diagnosed with canine peritoneal larval cestodiasis (Mesocestoides spp.). Veterinary Parasitology, 180(3-4):256-61.

  23. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Cragt S, Fagan AM, Iwatsubo T, Jack CR Jr, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH. (2011). Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's Disease. Alzheimer's & Dementia, 7(3):280-292.

  24. Farias ST, Mungas D, Reed B, Carmichael O, Beckett L, Harvey D, Olichney J, Simmons A, DeCarli C. (2011). Maximal brain size remains an important predictor of cognition in old age, independent of current brain pathology. Neurobiology of Aging, 33(8):1758-68.

  25. Stoddard J, Beckett L, Simon TJ. (2011). Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome. Journal of Neurodevelopmental Disorders, 3(1):76-85.

  26. Rizzo A, Beckett LA, Baier BS, Isseroff RR. (2011). The linear excisional wound: an improved model for human ex-vivo wound epithelialization studies. Skin Research and Technology, 18(1):125-32.

  27. Roberto R, Fritz A, Hagar Y, Boice B, Skalsky A, Hwang H, Beckett L, McDonald C, Gupta M. (2011). The Natural History of Cardiac and Pulmonary Function Decline in Patients with Duchenne Muscular Dystrophy. Spine, 36(15):E1009-17.

  28. Donohue MC, Gamst AC, Thomas RG, Xu R, Beckett L, Petersen RC, Weiner MW, Aisen P. (2010). The relative efficiency of time-to-threshold and rate of change in longitudinal data. Contemporary Clinical Trials, 32(5):685-693.

  29. Carmichael O, Schwarz C, Drucker D, Fletcher E, Harvey D, Beckett L, Jack CR Jr, Weiner M, DeCarli C. (2010). Alzheimer's Disease Neuroimaging Initiative. Longitudinal Changes in White Matter Disease and Cognition in the First Year of the Alzheimer's Disease Neuroimaging Initiative. Archives of Neurology, 67(11):1370-8.

  30. Lim BS, Leung JW, Lee J, Yen D, Beckett L, Tancredi D, Leung FW. (2010). Effect of ERCP Mechanical Simulator (EMS) Practice on Trainees' ERCP Performance in the Early Learning Period: US Multicenter Randomized Controlled Trial. The American Journal of Gastroenterology, 106(2):300-6.

  31. Krig SR, Miller JK, Frietze S, Beckett LA, Neve RM, Farnham PJ, Yaswen PI, Sweeney CA. (2010). ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells. Oncogene, 29(40):5500-10.

  32. Mungas D, Beckett L, Harvey D, Tomaszewski Farias S, Reed B, Carmichael O, Olichney J, Miller J, DeCarli C. (2010). Heterogeneity of Cognitive Trajectories in Diverse Older Persons. Psychology and Aging, 25(3):606-19.

  33. Prionas ND, Lindfors KK, Ray S, Huang SY, Beckett LA, Monsky WL, Boone JM. (2010). Contrast-enhanced Dedicated Breast CT: Initial Clinical Experience. Radiology, 256(3):714-23.

  34. Reed BR, Mungas D, Tomaszewski Farias S, Harvey D, Beckett L, Widaman K, Hinton L, DeCarli C. (2010). Measuring cognitive reserve based on the decomposition of episodic memory variance. Brain, 33(8):2196-2209.

  35. Nettiksimmons J, Harvey D, Brewer J, Carmichael O, DeCarli C, Jack CR Jr., Petersen R, Shaw LM, Trojanowski JQ, Weiner MW, Beckett L. (2010). The Alzheimer's Disease Neuroimaging Initiative. Subtypes based on cerebrospinal fluid and magnetic resonance imaging markers in normal elderly predict cognitive decline. Neurobiology of Aging, 31(8):1419-28.

  36. Hinton L, Carter K, Reed B, Beckett L, Lara E, DeCarli C, Mungas D. (2010). Recruitment of a Community-Based Cohort for Research on Diversity and Risk of Dementia. Alzheimer Disease and Associated Disorders, 24(3):234-41.

  37. Carmichael O, Mungas D, Beckett L, Harvey D, Tomaszewski Farias S, Reed B, Olichney J, Miller J, DeCarli C. (2010). MRI predictors of cognitive change in a diverse and carefully characterized elderly population. Neurobiology of Aging, 33(1):83-95.

  38. Ho C, Sangha R, Beckett L, Tanaka M, Lau DH, Eisen DB, Burich RA, Luciw P, Khan I, Mack PC, Gandara DR, Davies AM. (2010). Escalating weekly doses of cetuximab and correlation with skin toxicity: A phase I study. Investigational New Drugs, 29(4):680-7.

  39. Villablanca AC, Beckett LA, Li Y, Leatherwood S, Gill SK, Giardina EGV, Taylor AL, Barron C, Foody JM, Haynes S, D'Onofrio G. (2010). Outcomes of comprehensive heart care programs in high-risk women. Journal of Women's Health, 19(7):1313-25.

  40. Risacher SL, Shen L, West JD, Kim S, McDonald BC, Beckett LA, Harvey DJ, Jack CR Jr., Weiner MW, Saykin AJ, and the Alzheimer's Disease Neuroimaging Initiative (ADNI). (2010). Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort. Neurobiology of Aging, 31(8):1401-18.

  41. Aisen PS, Petersen RC, Donohue MC, Gamst A, Raman R, Thomas RG, Walter S, Trojanowski JQ, Shaw LM, Beckett LA, Jack CR Jr., Jagust W, Toga AW, Saykin AJ, Morris JC, Green RC, Weiner MW. (2010). Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans. Alzheimer's & Dementia, 6(3):239-46.

  42. Beckett LA, Harvey DJ, Gamst A, Donohue M, Kornak J, Zhang H, Kuo JH. Alzheimer's Disease Neuroimaging Initiative. (2010). The Alzheimer's Disease Neuroimaging Initiative: Annual change in biomarkers and clinical outcomes. Alzheimer's and Dementia, 6(3):257-64.

  43. Weiner MW, Aisen PS, Jack CR Jr., Jagust WJ Trojanowski JQ, Shaw L, Saykin AJ, Morris JC, Cairns N, Beckett LA, Toga A, Green R, Walter S, Soares H, Snyder P, Siemers E, Potter W, Cole PE, Schmidt M. (2010). The Alzheimer's Disease Neuroimaging Initiative: Progress Report and Future Plans. Alzheimer's and Dementia, 6(3):202-11.e7.

  44. Harvey DJ, Weng Q, Beckett LA. (2010). On an asymptotic distribution of dependent random variables on a 3-dimensional lattice. Statistics & probability letters, 80(11-12):1015-21.

  45. Dodd AR, Nelson-Mooney K, Greenhalgh DG, Beckett LA, Li Y, Palmieri TL. (2010). The Effect of Hand Burns on Quality of Life in Children. Journal of Burn Care and Research, 31(3):414-22.

  46. Graue-Hernandez EO, Mannis MJ, Eliasieh K, Greasby TA, Beckett LA, Bradley JC, Schwab IR. (2010). Salzmann Nodular Degeneration. Cornea, 29(3):383-9.

  47. Petersen RC, Aisen PS, Beckett LA, Donohue MC, Gamst AC, Harvey DJ, Jack CR Jr., Jagust WJ, Shaw LM, Toga AM, Trojanowski JQ, Weiner MW. (2010). Alzheimer's Disease Neuroimaging Initiative (ADNI): clinical characterization. Neurology, 74(3):201-9.

  48. Tran S, Lewalski EA, Dwyre DM, Hagar Y, Beckett L, Janatpour KA, Holland PV. (2010). Does donating blood for the first time during a national emergency create a better commitment to donating again? Vox Sanguinis, 96(3pt1):e219-24.

  49. DeNardo GL, Mirick G, Hok S, DeNardo SJ, Beckett LA, Adamson GN, Balhorn R. (2009). Molecular specific and cell selective cytotoxicity induced by a novel synthetic HLA-DR antibody mimic for lymphoma and leukemia. International Journal of Oncology, 34(2):511-6.

  50. Barakatt ET, Romano PS, Riddle DL, Beckett LA, Kravitz R. (2009). An Exploration of Maitland's Concept of Pain Irritability in Patients with Low Back Pain. The Journal of Manual & Manipulative Therapy, 17(4):196-205.

  51. Barakatt ET, Romano PS, Riddle DL, Beckett LA. (2009). The Reliability of Maitland's Irritability Judgments in Patients With Low Back Pain. Journal of Manual & Manipulative Therapy, 17(3):135-40.

  52. Mack PC, Holland WS, Burich RA, Sangha R, Solis LJ, Li Y, Beckett LA, Lara PN Jr., Davies AM, Gandara DR. (2009). EGFR Mutations Detected in Plasma Are Associated With Patient Outcomes in Erlotinib Plus Docetaxel-Treated Non-small Cell Lung Cancer. Journal of Thoracic Oncology, 4(12):1466-72.

  53. Workman HC, Miller JK, Ingalla EQ, Kaur RP, Yamamoto DI, Beckett LA, Yong LJT, Cardiff RD, Borowsky AD, Carraway KL, Sweeney C, Carraway KL III. (2009). The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells. Breast Cancer Research, 11(5):R70.

  54. Davies AM, Ho C, Beckett L, Lau D, Scudder SA, Lara PN, Perkins N, Gandara DR. (2009). Intermittent Erlotinib in Combination with Pemetrexed: Phase I Schedules Designed to Achieve Pharmacodynamic Separation. Journal of Thoracic Oncology, 4(7):862-8.

  55. Fassbender C, Zhang H, Buzy WM, Cortes CR, Mizuiri D, Beckett L, Schweitzer JB. (2009). A lack of default network suppression is linked to increased distractibility in ADHD. Brain Research, 27(6):114-28.

  56. Hinton L, Hagar Y, West N, Gonzalez HM, Mungas D, Beckett L, Haan MN. (2009). Longitudinal Influences of Partner Depression on Cognitive Functioning in Latino Spousal Pairs. Dementia and Geriatric Cognitive Disorders, 27(6):491-500.

  57. Anuurad E, Tracy RP, Pearson TA, Beckett L, Berglund L. (2009). Comparison of C-reactive protein and metabolic syndrome as cardiovascular risk factors in African-Americans and European-Americans. American Journal of Cardiology, 15(103(4)):523-7.

  58. Shaw SC, Kent MS, Gordon IK, Collins CJ, Greasby T, Beckett LA, Hammond GM, Korups KS. (2009). Temporal changes in characteristics of injection-site sarcomas in cats: 392 cases (1990-2006). Journal of the American Veterinary Medicine Association, 234(3):376-80.

  59. Lee K, Park EK, Stoecklin-Marois M, Koivun ME, Gee SJ, Hammock BD, Beckett LA, Schenker MB. (2009). Occupational paraquat exposure of agricultural workers in large Costa Rican farms. International Archives Occupational Environmental Health, 82(4):455-62.

  60. Gerscovich EO, Park CW, Dulude MZ, McGahan JP, Stein-Wexler R, Greasby TA, Beckett LA. (2008). Increased rotational mobility of the testis after vasectomy: a sonographic study. Journal Ultrasound Medicine, 27(12):1667-72.

  61. Szubin R, Chang WL, Greasby T, Beckett L, Baumgarth N. (2008). Rigid interferon-alpha subtype responses of human plasmacytoid dendritic cells. Journal of Interferon & Cytokine Research, 28(12):749-63.

  62. Ray S, Hagge R, Gillen M, Cerejo M, Shakeri S, Beckett L, Greasby T, Badawi RD. (2008). Comparison of two-dimensional and three-dimensional iterative watershed segmentation methods in hepatic tumor volumetrics. Medical Physics, 35(12):749-63.

  63. DeNardo GL, Natarajan A, Hok S, Mirick G, DeNardo SJ, Corzett M, Sysko V, Lehmann J, Beckett L, Balhorn R. (2008). Nanomolecular HLA-DR10 antibody mimics: A potent system for molecular targeted therapy and imaging. Cancer Biotherapy & Radiopharmaceuticals, 23(6):783-95.

  64. Fenton JJ, Cai Y, Green P, Beckett LA, Franks P, Baldwin LM. (2008). Trends in colorectal cancer testing among Medicare subpopulations. American Journal of Preventive Medicine, 35(3):194-202.

  65. You Z, Dong Y, Kong X, Beckett LA, Gandour-Edwards R, Melamed J. (2008). Midkine is a NF-kappaB-inducible gene that supports prostate cancer cell survival. BMC Medical Genomics, 14(1):6.

  66. McLaughlin BE, Baumgarth N, Bigos M, Roederer M, De Rosa SC, Altman JD, Nixon DF, Ottinger J, Li J, Beckett L, Shacklett BL, Evans TG, Asmuth DM. (2008). Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part II: Panel performance across different instrument platforms. Cytometry: Part A, 73A(5):411-20.

  67. Lakshminarayanan R, Li Y, Janatpour K, Beckett L, Jialal I. (2007). Detection by immunofixation of M proteins in hypogammaglobulinemic patients with normal serum protein electrophoresis results. American Journal of Clinical Pathology, 127(5):746-51.

  68. Davies AM, Ho C, Metzger AS, Beckett LA, Christensen S, Tanaka M, Lara PN, Lau DH, Gandara DR. (2007). Phase I study of two different schedules of bortezomib and pemetrexed in advanced solid tumors with emphasis on non-small cell lung cancer. Journal of Thoracic Oncology, 2(12):1112-6.

  69. Umutyan A, Chiechi C, Beckett LA, Paterniti DA, Turrell C, Gandara DR, Davis SW, Wun T, Chen MS Jr, Lara PN Jr. (2007). Overcoming barriers to cancer clinical trial accrual: impact of a mass media campaign. Cancer, 112(1):212-19.

  70. Pan XL, HW Day, W Wang, LA Beckett and MB Schenker. (2005). Residential Proximity to Naturally Occurring Asbestos and Mesothelioma Risk in California. American Journal of Respiratory and Critical Care Medicine, 172(8):1019-25.

  71. Henn, Jennifer B, Chu-Hao Liu, Rick W Kasten, Brian A VanHorn, Laurel A Beckett, Philip H Kass and Bruno B Chomel. (2005). Seroprevalence of antibodies against Bartonella species and evaluation of risk factors and clinical signs associated with seropositivity in dogs. American Journal of Veterinary Research, 66(4):688-94.

  72. Beckett, L A, Tancredi, DJ and Wilson, RS. (2004). Multivariate longitudinal models for complex change processes. Stat Med, 23(2):231-9

  73. Packianathan S, Mehta RG, Mehta RR, Hall WH, Boerner PS, Beckett LA, Vijayakumar S. (2004). Designing a randomized phase I/II prostate cancer chemoprevention trial using 1alpha-hydroxy-24-ethyl-cholecalciferol, an analogue of vitamin D3. Cancer, 10(6):357-67.

  74. Shi XB, Gandour-Edwards R, Beckett LA, Deitch AD, de Vere White RW. (2004). A modified yeast assay used on archival samples of localized prostate cancer tissue improves the detection of p53 abnormalities and increases their predictive value. BJU (British Journal of Urology) International, 94(7):996-1002.

  75. Murray AM, Bennett DA, Mendes de Leon CF, Beckett LA, Evans DA. (2004). A longitudinal study of parkinsonism and disability in a community population of older people. Journal of Gerontology: Medical Sciences, 59(8):864-70.

  76. McCann, Judith J, David W Gilley, Julia L Bienias, Laurel A Beckett and Denis A Evans. (2004). Temporal patterns of negative and positive behavior among nursing home residents with Alzheimer's disease. Psychol Aging, 19(2):336-45.

  77. Danhauer SC, McCann JJ, Gilley DW, Beckett LA, Bienias JL, Evans DA. (2004). Do behavioral disturbances in persons with Alzheimer's disease predict caregiver depression over time? Psychology and Aging,, 19(1):198-202.

  78. deVere White, Ralph W, Robert M Hackman, Stephanie E Soares, Laurel A Beckett, Yueju Li and Buxiang Sun. (2004). Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer. Urology, 63(2):259-63.

  79. Beckett, L A, D J Tancredi and R S Wilson. (2004). Multivariate longitudinal models for complex change processes. Stat Med, 23(2):231-9.

  80. Schenker, Marc B, Maria Stoecklin, Kiyoung Lee, Rafael Lupercio, R Jorge Zeballos, Paul Enright, Tamara Hennessy and Laurel A Beckett. (2004). Pulmonary function and exercise-associated changes with chronic low-level paraquat exposure. Am J Respir Crit Care Med, 170(7):773-9.

  81. Evans, Denis A, David A Bennett, Robert S Wilson, Julia L Bienias, Martha Clare Morris, Paul A Scherr, Liesi E Hebert, Neelum Aggarwal, Laurel A Beckett, Rajiv Joglekar, Elizabeth Berry-Kravis and Julie Schneider. (2003). Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status. Arch Neurol, 60(2):185-9.

  82. Wilson RS, LA Beckett, JL Bienias, DA Evans and DA Bennett. (2003). Terminal decline in cognitive function. Neurology, 60(11):1782-1787.

  83. Harvey, Danielle J, Laurel A Beckett and Dan M Mungas. (2003). Multivariate modeling of two associated cognitive outcomes in a longitudinal study. J Alzheimers Dis, 5(5):357-65.

  84. Bienias, Julia L, Laurel A Beckett, David A Bennett, Robert S Wilson and Denis A Evans. (2003). Design of the Chicago Health and Aging Project (CHAP). J Alzheimers Dis, 5(5):349-55.

  85. Bennett, D A, R S Wilson, J A Schneider, D A Evans, L A Beckett, N T Aggarwal, L L Barnes, J H Fox and J Bach. (2002). Natural history of mild cognitive impairment in older persons. Neurology, 59(2):198-205.

  86. Wilson, Robert S, Julie A Schneider, Lisa L Barnes, Laurel A Beckett, Neelum T Aggarwal, Elizabeth J Cochran, Elizabeth Berry-Kravis, Julie Bach, Jacob H Fox, Denis A Evans and David A Bennett. (2002). The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period. Arch Neurol, 59(7):1154-60.

  87. Wilson, R S, J A Schneider, L A Beckett, D A Evans and D A Bennett. (2002). Progression of gait disorder and rigidity and risk of death in older persons. Neurology, 58(12):1815-9.

  88. Wilson, Robert S, Laurel A Beckett, Lisa L Barnes, Julie A Schneider, Julie Bach, Denis A Evans and David A Bennett. (2002). Individual differences in rates of change in cognitive abilities of older persons. Psychol Aging, 17(2):179-93.

  89. deVere White, Ralph W, Robert M Hackman, Stephanie E Soares, Laurel A Beckett and Buxiang Sun. (2002). Effects of a mushroom mycelium extract on the treatment of prostate cancer. Urology, 60(4):640-4.

  90. Wilson, Robert S, L L Barnes, C F Mendes de Leon, N T Aggarwal, J S Schneider, J Bach, J Pilat, L A Beckett, S E Arnold, D A Evans and D A Bennett. (2002). Depressive symptoms, cognitive decline, and risk of AD in older persons. Neurology, 59(3):364-70.

  91. Gulsvik, A, LA Beckett, P Bakke, S Humerfelt, E Omenaas and FE Speizer. (2001). Standardized submaximal exercise testing in never smokers: a normative study. Clin. Physiol., 21(5):629-636.

  92. Hebert, LE, LA Beckett, PA Scherr and DA Evans. (2001). Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050. Alzheimer Dis. Assoc. Dis., 15(4):169-173.

  93. Dickerson, B C, I Goncharova, M P Sullivan, C Forchetti, R S Wilson, D A Bennett, L A Beckett and L deToledo-Morrell. (2001). MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease. Neurobiol Aging, 22(5):747-54.

  94. Ghoshal, N, F Garcia-Sierra, Y Fu, L A Beckett, E J Mufson, J Kuret, R W Berry and L I Binder. (2001). Tau-66: evidence for a novel tau conformation in Alzheimer's disease. J Neurochem, 77(5):1372-85.

  95. Hebert, L E, P A Scherr, J J McCann, L A Beckett and D A Evans. (2001). Is the risk of developing Alzheimer's disease greater for women than for men? Am J Epidemiol, 153(2):132-6.

  96. Hebert, L E, L A Beckett, P A Scherr and D A Evans. (2001). Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050. Alzheimer Dis Assoc Disord, 15(4):169-73.

  97. Dickerson, B C, I Goncharova, M P Sullivan, C Forchetti, R S Wilson, D A Bennett, L A Beckett and L deToledo-Morrell. (2001). MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease. Neurobiol Aging, 22(5):747-54.

  98. Beckett LA. (2000). Community-based studies of Alzheimer's disease: Statistical challenges in design and analysis. Statistics in Medicine, 19, 1469-1480

  99. Beckett LA, and Tancredi, DJ. (2000). Parametric empirical Bayes estimates of disease prevalence using stratified samples from community populations. Statistics in Medicine, 19, 681-695

  100. Beckett, LA and DJ Tancredi. (2000). Parametric empirical Bayes estimates of disease prevalence using stratifed samples from community populations. Stat. Med., 19(5):681-695.

  101. Wilson, RS, DA Bennett, DW Gilley, LA Beckett, JA Schneider and DA Evans. (2000). Progression of parkinsonism and loss of cognitive function in Alzheimer disease. Arch. Neurol., 57(6):855-860.

  102. Beckett, LA. (2000). Community-based studies of Alzheimer's disease: statistical challenges in design and analysis. Stat. Med., 19(11-12):1469-1480.

  103. Wilson, RS, DW Gilley, DA Bennett, LA Beckett and DA Evans. (2000). Hallucinations, delusions, and cognitive decline in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry, 69(2):172-177.

  104. Cronin-Stubbs, D, CFM De Leon, LA Beckett, TS Field, RJ Glynn and DA Evans. (2000). Six-year effect of depressive symptoms on the course of physical disability in community-living older adults. Arch. Intern. Med., 160(20):3074-3080.

  105. Wilson, RS, DA Bennett, DW Gilley, LA Beckett, LL Barnes and DA Evans. (2000). Premorbid reading activity and patterns of cognitive decline in Alzheimer disease. Arch. Neurol., 57(12):1718-1723.

  106. Hebert, LE, RS Wilson, DW Gilley, LA Beckett, PA Scherr, DA Bennett and DA Evans. (2000). Decline of language among women and men with Alzheimer's disease. J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci., 55(6):P354-P360.

  107. McCann, JJ, LE Hebert, LA Beckett, MC Morris, PA Scherr and DA Evans. (2000). Comparison of informal caregiving by black and white older adults in a community population. J. Am. Geriatr. Soc., 48(12):1612-1617.

  108. Wilson, RS, D W Gilley, D A Bennett, L A Beckett and D A Evans. (2000). Person-specific paths of cognitive decline in Alzheimer's disease and their relation to age. Psychol Aging, 15(1):18-28.

  109. Glynn, RJ, LA Beckett, LE Hebert, MC Morris, PA Scherr and DA Evans. (1999). Current and remote blood pressure and cognitive decline. JAMA-J. Am. Med. Assoc., 281(5):438-445.

  110. Bennett, DA, KM Shannon, LA Beckett and RS Wilson. (1999). Dimensionality of parkinsonian signs in aging and Alzheimer's disease. J. Gerontol. Ser. A-Biol. Sci. Med. Sci., 54(4):M191-M196.

  111. De Leon, CFM, TA Glass, LA Beckett, TE Seeman, DA Evans and LF Berkman. (1999). Social networks and disability transitions across eight intervals of yearly data in the New Haven EPESE. J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci., 54(3):S162-S172.

  112. Wilson, RS, DA Bennett, LA Beckett, MC Morris, DW Gilley, JL Bienias, PA Scherr and DA Evans. (1999). Cognitive activity in older persons from a geographically defined population. J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci., 54(3):P155-P160.

  113. Wilson, RS, LA Beckett, DA Bennett, MS Albert and DA Evans. (1999). Change in cognitive function in older persons from a community population - Relation to age and Alzheimer disease. Arch. Neurol., 56(10):1274-1279.

  114. Mufson, EJ, EY Chen, EJ Cochran, LA Beckett, DA Bennett and JH Kordower. (1999). Entorhinal cortex beta-amyloid load in individuals with mild cognitive impairment. Exp. Neurol., 158(2):469-490.

  115. Morris, MC, LA Beckett, PA Scherr, LE Hebert, DA Bennett, TS Field and DA Evans. (1998). Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease. Alzheimer Dis. Assoc. Dis., 12(3):121-126.

  116. Deleon, CFM, LA Beckett, GG Fillenbaum, DB Brock, LG Branch, DA Evans and LF Berkman. (1997). Black-white differences in risk of becoming disabled and recovering from disability in old age: A longitudinal analysis Of two Epese Populations. Am. J. Epidemiol., 145(6):488-497.

  117. McCann, JJ, DW Gilley, LE Hebert, LA Beckett and DA Evans. (1997). Concordance between direct observation and staff rating of behavior in nursing home residents with Alzheimer's disease. J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci., 52(2):P63-P72.

  118. Evans, DA, LA Beckett, TS Field, L Feng, MS Albert, DA Bennett, B Tycko and R Mayeux. (1997). Apolipoprotein E epsilon 4 and incidence of Alzheimer disease In a Community Population of Older Persons. JAMA-J. Am. Med. Assoc., 277(10):822-824.

  119. Gilley, DW, RS Wilson, LA Beckett and DA Evans. (1997). Psychotic symptoms and physically aggressive behavior in Alzheimer's disease. J. Am. Geriatr. Soc., 45(9):1074-1079.

  120. Evans, DA, LE Hebert, LA Beckett, PA Scherr, MS Albert, MJ Chown, DM Pilgrim and JO Taylor. (1997). Education and other measures of socioeconomic status and risk Of Incident Alzheimer Disease in a Defined Population of Older persons. Arch. Neurol., 54(11):1399-1405.

  121. Bennett, DA, KM Shannon, LA Beckett, CG Goetz and RS Wilson. (1997). Metric properties of nurses' ratings of parkinsonian signs with a modified Unified Parkinson's Disease Rating Scale. Neurology, 49(6):1580-1587.

  122. Beckett, LA, DB Brock, JH Lemke, CFM Deleon, JM Guralnik, GG Fillenbaum, LG Branch, TT Wetle and DA Evans. (1996). Analysis of change in self-reported physical function among older persons in four population studies. Am. J. Epidemiol., 143(8):766-778.

  123. Bennett, DA, LA Beckett, AM Murray, KM Shannon, CG Goetz, DM Pilgrim and DA Evans. (1996). Prevalence of Parkinsonian signs and associated mortality in a community population of older people. N. Engl. J. Med., 334(2):71-76.

  124. Hebert, LE, PA Scherr, LA Beckett, MS Albert, DM Pilgrim, MJ Chown, HH Funkenstein and DA Evans. (1995). Age-specific Incidence of Alzheimers-disease in a Community Population. JAMA-J. Am. Med. Assoc., 273(17):1354-1359.

  125. Deleon, CFM, GG Fillenbaum, CS Williams, DB Brock, LA Beckett and LF Berkman. (1995). Functional Disability Among Elderly Blacks and Whites in 2 Diverse Areas - the New-haven and North-carolina Epese. Am. J. Public Health, 85(7):994-998.

  126. Fortin, PR, RA Lew, MH Liang, EA Wright, LA Beckett, TC Chalmers and RI Sperling. (1995). Validation of a Metaanalysis - the Effects of Fish-oil in Rheumatoid-arthritis. J. Clin. Epidemiol., 48(11):1379-1390.

  127. Beckett, LA and Diaconis, PW. (1994). Spectral Analysis for Discrete Longitudinal Data. Advances in Mathematics, 103, 107-128

  128. Mayers, DL, AJ Japour, JM Arduino, SM Hammer, R Reichman, KF Wagner, R Chung, J Lane, CS Crumpacker, GX Mcleod, LA Beckett, CR Roberts, D Winslow, D Burke, N Ruiz, M Fujimarajustice, P Kernozek, J Koch, C Brewer, C Hicks, ME Shellie, L Lorizlim, C Smalls, A Hamilton, F McCutchan, E Sandersbuell, O Weislow, A Fowler, J Lane and L Merritt. (1994). Dideoxynucleoside Resistance Emerges With Prolonged Zidovudine Monotherapy. Antimicrob. Agents Chemother., 38(2):307-314.

  129. Resnick, NM, LA Beckett, LG Branch, PA Scherr and T Wetle. (1994). Short-term Variability of Self-report of Incontinence in Older Persons. J. Am. Geriatr. Soc., 42(2):202-207.

  130. Degruttola, V, LA Beckett, RW Coombs, JM Arduino, HH Balfour, S Rasheed, FB Hollinger, MA Fischl, P Volberding and Tact Group. (1994). Serum p24 Antigen Level as an Intermediate End-point in Clinical-trials of Zidovudine in People Infected With Human- Immunodeficiency-virus Type-1. J. Infect. Dis., 169(4):713-721.

  131. Japour, AJ, DL Mayers, VA Johnson, DR Kuritzkes, LA Beckett, JM Arduino, J Lane, RJ Black, PS Reichelderfer, RT Daquila, CS Crumpacker, H Balfour, A Erice, R Coombs, D Katzenstein, J Lathey, D Richman, K Mcintosh, S Rangan, R Reichman, W Scott, M Ussery, L Abrams, F McCutchan, D Burke, L Gardner, C Roberts, R Chung, C Hicks, E Shellie, A Fowler, L Merritt, M Fujimurajustice, N Ruiz, K Wagner and M Gail. (1993). Standardized Peripheral-blood Mononuclear Cell-culture Assay For Determination of Drug Susceptibilities of Clinical Human- Immunodeficiency-virus Type-1 Isolates. Antimicrob. Agents Chemother., 37(5):1095-1101.

  132. Hebert, LE, PA Scherr, LA Beckett, MS Albert, B Rosner, JO Taylor and DA Evans. (1993). Relation of Smoking and Low-to-moderate Alcohol-consumption to Change in Cognitive Function - a Longitudinal-study in a Defined Community of Older Persons. Am. J. Epidemiol., 137(8):881-891.

  133. Dezube, BJ, AB Pardee, B Chapman, LA Beckett, JA Korvick, WJ Novick, J Chiurco, P Kasdan, CM Ahlers, LT Ecto and CS Crumpacker. (1993). Pentoxifylline Decreases Tumor-necrosis-factor Expression and Serum Triglycerides in People With Aids. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 6(7):787-794.

  134. Beckett, LA, PA Scherr and DA Evans. (1992). Population Prevalence Estimates From Complex Samples. J. Clin. Epidemiol., 45(4):393-402.

  135. Hebert, LE, PA Scherr, LA Beckett, HH Funkenstein, MS Albert, MJ Chown and DA Evans. (1992). Relation of Smoking and Alcohol-consumption to Incident Alzheimers-disease. Am. J. Epidemiol., 135(4):347-355.

  136. Gillman, MW, NR Cook, B Rosner, LA Beckett, DA Evans, ME Keough, JO Taylor and CH Hennekens. (1992). Childhood Blood-pressure Tracking Correlations Corrected for Within-person Variability. Stat. Med., 11(9):1187-1194.

  137. Austin, JK, MW Risinger and LA Beckett. (1992). Correlates of Behavior Problems in Children With Epilepsy. Epilepsia, 33(6):1115-1122.

  138. Dezube, BJ, AB Pardee, LA Beckett, CM Ahlers, L Ecto, J Allenryan, A Anisowicz, R Sager and CS Crumpacker. (1992). Cytokine Dysregulation in Aids - Invivo Overexpression of Messenger-rna of Tumor-necrosis-factor-alpha and its Correlation With That of the Inflammatory Cytokine gro. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 5(11):1099-1104.

  139. Beckett, LA, B Rosner, AF Roche and S Guo. (1992). Serial Changes in Blood-pressure From Adolescence Into Adulthood. Am. J. Epidemiol., 135(10):1166-1177.

  140. Carpen, O, ML Dustin, TA Springer, JA Swafford, LA Beckett and JP Caulfield. (1991). Motility and Ultrastructure of Large Granular Lymphocytes on Lipid Bilayers Reconstituted With Adhesion Receptors LFA-1, ICAM-1, and 2 Isoforms of LFA-3. J. Cell Biol., 115(3):861-871.

  141. Evans D, Scherr P, Cook N, Albert M, Funkenstein H, Smith L, Hebert L, Wetle T, Branch L, Chown M, Hennekens CH and Taylor JO. (1990). Estimated Prevalence of Alzheimer's Disease in the United States. Milbank Quarterly, 68, 267-289

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