Education:

BS - National Chung Hsing University, Taichung, Taiwan, R.O.C. (1984)
MS - National Chung Hsing University, Taichung, Taiwan, R.O.C. (1986)
PhD - Texas A&M University (1997)

Experience:

June 26, 2006 – Nov. 27, 2007 - Associate Member, Department of Biostatistics, St. Jude Children's  
 Research Hospital, Memphis, TN
July 1, 2001 - June 25, 2006 - Assistant Member, Department of Biostatistics, St. Jude Children's   
Research Hospital, Memphis, TN
Nov. 2001 -- Nov. 27, 2007 - Adjunct Professor, Department of Mathematical Sciences
University of Memphis, Memphis, TN

Research Interests:

• Lack-of-fit tests
• Cure models (including survival analysis)
• Semiparametric and nonparametric regression
• Generalized linear models
• Longitudinal data analysis
• Statistical methodology for genetic data
• Large sample theory

Selected Publications

Statistics Journal Publications:

1. Li, C.S. and Hunt, D.L. (2008). A linear B-spline threshold dose-response model with dose-specific response variation applied to developmental toxicity studies. JMASM, accepted
2. Hunt, D.L., Rai, S.N., and Li, C.S. (2008). Summary of dose-response modeling for developmental toxicity studies. Dose-Response, 6, 352-368.
3. Eubank, R. and Li, C.S. (2008). A diagnostic test for parallelism. International Journal of Statistical Sciences, 7, 13-29.
4. Li, C.S. and Tu, W. (2007). A spline-based lack-of-fit test for independent variable effect in Poisson regression. Journal of Modern Applied Statistical Method, 6, 239-247.
5. Hunt, D. and Li, C.S. (2006). A regression spline model for developmental data. Toxicological Sciences, 92, 329-334.
6. Li, C.S.  (2005). Using local linear kernel smoothers to test the lack of fit of nonlinear regression models. Statistical Methodology, 2, 267-284.
7. Li, C.S. (2005). Testing lack of fit for heteroscedastic nonlinear regression models via locally weighted least squares regression. Far East Journal of Theoretical Statistics, 16, 29-54.
8. Eubank, R.L., Li, C.S., and Wang, S. (2005). Testing lack-of-fit of parametric regression models using nonparametric regression techniques. Statistica Sinica, 15,135-152.
9. Li, C.S. and Cheng, C. (2004). Stable classification with applications to microarray data. Computational Statistics & Data Analysis, 47, 599-609.
10. Li, C.S. and Hunt, D. (2004). Regression splines for threshold selection with application to a random-effects logistic dose-response model. Computational Statistics & Data Analysis, 46, 1-9.
11. Li, C.S., Liang, H., Hsieh, Y.H., and Twu, S.J. (2003). Comparison of viral trajectories in AIDS studies by using nonparametric mixed-effects models. Journal of Modern Applied Statistical Method, 2(2), 443-450.
12. Li, C.S.  (2003). A lack-of-fit test for heteroscedastic regression models via cosine-series smoothers. The Australian & New Zealand Journal of Statistic, 45(4), 477-489.
13. McSorley, E.O., Lu, J.C., and Li, C.S. (2002). Performance of parameter-estimates in step-stress accelerated life-tests with various sample-sizes. IEEE Transactions on Reliability, 51(3), 271-277.
14. Li, C.S. and Taylor, J.M.G. (2002). A semiparametric accelerated failure time cure model. Stat Med, 21, 3235-3247.
15. Li, C.S. and Taylor, J.M.G. (2002). Smoothing covariate effects in cure models. Communications in Statistics, 31(3), 477-493.
16. Li, C.S., Taylor, J.M.G., and Sy, J.P. (2001). Identifiability of cure models. Statistics & Probability Letters, 54(4), 389-395.
17. Li, C.S. (2001). Testing for linearity in generalized linear models using kernel smoothing. Journal of Statistical Computation and Simulation, 69(4), 339-351.
18. Chen, D., Li, C.S., Lu, J.C., and Park, J. (2000). Parameter estimation for bivariate shock models with censored data. Aust N Z J Stat, 42, 323-336.
19. Li, C.S. (1999).Testing lack of fit of regression models under heteroscedasticity. Can J Stat, 27, 485-496.
20. Li, C.S., Lu, J.C., Park, J., Kim, K., Brinkley, P.A., and Peterson, J.P. (1999). Multivariate zero-inflated Poisson models and their applications. Technometrics, 41, 29-38.
21. Chen, D., Lu, J.C., Hughes-Oliver, J.M., and Li, C.S. (1998). Asymptotic properties of maximum likelihood estimates for a bivariate exponential distribution and mixed censored data. Metrika, 48,109-125.

Book Chapters:

1. Li, C.S. (2007). Nonparametric regression techniques in survival analysis. A contributed book volume on Quantitative Medical Data Analysis Using Mathematical Tools and Statistical Techniques, Eds.  D. Hong & Y. Shyr, World Scientific Publishing Company PTE LTD, Singapore.
2. Li, C.S. (2004) Failure-time model. Encyclopedia of Biopharmaceutical Statistics, Marcel Dekker, Inc.
3. Nguyen, D.V., Senturk, D., Harvey, D.J., and Li, C.S. (2008) Sample size and power in genomics studies. Computational Biology: New Research, Russe, A.S. (ed), Nova Science Publishers, New York, in press.

Medical Publications:

1. Smith, M.M., Chen, P.C.Y., Li, C.S., Ramanujam, S. and Cheung, A.T.W. (2008). Whole blood viscosity and microvascular abnormalities in Alzheimer's disease. Clinical Hemorheology and Microcirculation, accepted
2. Helton, K.J., Paydar, A., Glass, J., Weirich, E.M., Hankins, J., Li, C.S., Smeltzer, M., Wang, W.C., Ware, R.E., and Ogg, R.J. (2009). Arterial spin-labeled perfusion combined with segmentation techniques to evaluate cerebral blood flow in white and gray matter of children with sickle cell anemia. Pediatric Blood and Cancer, 52, 85-91
3. Bateman, L.M., Li, C.S., and Seyal, M. (2008). Ictal hypoxemia in localization-related epilepsy: analysis of incidence, severity and risk factors. Brain, 131, 3239-3245
4. Morris, E.B., Shelso, J., Smeltzer, M., Thomas, N.A., Karimove, E.J., Li, C.S., Merchant, T., Gajjar, A., and Kaste, S.C. (2008). The use of bone age for bone mineral density interpretation in a cohort of pediatric brain tumor patients. Pediatric Radiology, 38, 1285-1292
5. McCarville, M.B., Whittle, S., Goodin, G., Li, C.S., Smeltzer, M., Hale, G., and Kaufman, R. (2008). Clinical and CT features of benign pneumatosis intestinalis in pediatric hematopoietic stem cell transplant and oncology patients. Pediatric Radiology, 38, 1074-1083
6. Hankins, J., Forner, G., McCarville, B., Smeltzer, M., Wang, W., Li, C.S., and Ware, R. (2008). The natural history of conditional transcranial Doppler flow velocities in children with sickle cell anemia. British Journal of Hematology, 142, 94-99
7. Lim, Y., Vasu, V.T., Valacchi, G., Leonard, S., Aung, H.H., Schock, B.C., Kenyon, N.J., Li, C.S., Traber, M.G., and Cross, C.E. (2008). Severe vitamin E deficiency modulates airway allergic inflammatory responses in the murine asthma model. Free Radical Research, 42, 387-396
8. Burton, A.R., Vincent, E., Lennon, G.P., Smeltzer, M., Li, C.S., Haskins, K., Hutton, J., Tisch, R.M., Sercarz, E.E., Santanmaria, P., Workman, C.J., and Vignali, D.A.A. (2008). On the pathogenicity of autoantigen-specific T cell receptors. Diabetes, 57, 1321-1330
9. Helton, K.J., Weeks, J.K., Phillips, N.S., Zou, P., Kun, L.E., Khan, R.B., Gajjar, A.J., Fouladi, M., Broniscer, A., Boop, F., Li, C.S., and Ogg, R.J. (2008). Diffusion tensor imaging of brainstem tumors: axonal degeneration of motor and sensory tracts. Journal of Neurosurgery: Pediatrics, 1, 270-276
10. McCarville, M.B., Goodin, G.S., Fortner, G., Li, C.S., Smeltzer, M.P., Adams, R., and Wang, W. (2008). Evaluation of a comprehensive transcranial Doppler screening program for children with sickle cell anemia. Pediatric Blood and Cancer,  50, 818-821
11. Martin, M.B., Li, C.S., Rowland, C.C., Howard, S.C., and Kaste, S.C. (2008). Correlation of bone age, dental age, and chronological age in survivors of childhood acute lymphoblastic leukemia. International Journal of Paediatric Dentistry, 18, 217-223
12. Hankins, J.S., Wynn, L.W., Brugnara, C., Hillery, C., Li, C.S., and Wang, W.C. (2008). Phase I study of magnesium pidolate in combination with Hydroxyurea for children with sickle cell anemia. British Journal of Haematology, 140(1), 80-85.
13. Hankins, J., Helton, K., McCarville, B., Li, C.S., Wang, W., and Ware, R.E. (2008). Preservation of spleen and brain functions in children with sickle cell anemia treated with hydroxyurea. Pediatric Blood and Cancer, 50(2), 293-297.
14. Anghelescu, D.L., Burgoyne, L.L., Liu, T., Li, C.S., Pui, C.H., Hudson, M.M., Furman, W.L., and Sandlund, J.T. (2007). Clinical and diagnostic imaging findings predict anesthetic complications in children presenting with malignant mediastinal masses. Pediatric Anesthesia, 17(11), 1090–1098.
15. Lyle, C.E., Wilson, M.W, Li, C.S., and Kaste, S.C. (2007). Comparison of orbital volumes in enucleated patients with unilateral retinoblastoma: hydroxyapatite implants versus silicone implants. Ophthalmic Plastic and Reconstructive Surgery, 23(5), 393-396.
16. Hankins, J., Hinds, P., Day, S., Carroll, Y., Li, C.S., Garvie, P., and Wang, W. (2007). Therapy preference and decision-making among patients with severe sickle cell anemia and their families. Pediatric Blood and Cancer, 48, 705-710.
17. McCarville, B., Goodin, G., Whittle, S., Smeltzer, M., Li, C.S., and Shulkin, B. (2007). Correlation of PET-CT findings and histology in children with solid malignancies. Pediatric Radiology, 37 (Suppl 1), S46-S70 Abstract #31.
18. Funk, A.J., Mandrell, T., Lokey, SJ, Kosanke, S., Li CS, and Potter, C.F. (2007).Effects of leukotriene receptor antagonism on pulmonary morphology in rat pup lungs exposed to hyperoxia.  Comparative Medicine, 57(2), 186-192.
19. Shan, Z.Y., Liu, J.Z., Glass, J.O., Gajjar, A., Li, C.S., and Reddick, W.E. (2006). Quantitative morphologic evaluation of white matter in survivors of childhood medulloblastoma. Magnetic Resonance Imaging, 24, 1015-1022.
20. Glass, J.O., Reddick, W.E., Li, C.S., Laningham, F.H., Helton, K.J., and Pui, C.H. (2006). Computer-aided detection of therapy-induced leukoencephalopathy in pediatric acute lymphoblastic leukemia patients treated with intravenous high-dose methotrexate. Magnetic Resonance Imaging, 24, 785-791.
21. McCarville, M.B., Streck, C., Dickson, P.V., Li, C.S., Nathwani, A.C., and Davidoff, A.M. (2006). Angiogenesis Inhibitors in a Murine Neuroblastoma Model: Quantitative Assessment of Intratumoral Blood Flow with Contrast-enhanced Gray-Scale US. Radiology, 240, 73-81.
22. McCarville, M.B., Lederman, H.M., Santana, V.M., Daw, N.C., Shochat, S., and Li, C.S., and Kaufman, RA.  (2006). Distinguishing benign from malignant pulmonary nodules with helical chest CT in children with malignant solid tumors. Radiology, 239, 514-520.
23. Helton, K.J., Phillips, N.S., Khan, R.B., Boop, F.A., Sanford, R.A., Zou, P., Li, C.S., Langston, J.W., and Ogg, R.J. (2006). Diffusion tensor imaging of tract involvement in children with pontine tumors. American Journal of Neuroradiology, 27,786-793.
24. Metzger, M.L., Hudson, M.M., Somes, G., Shorr, R., Li, C.S., Krasin, M.J., Shelso, J., Pui, C.H., and Howard, S.C. (2006). White race as a risk factor for hypothyroidism after treatment for pediatric Hodgkin’s lymphoma. Journal of Clinical Oncology, 24, 1516-1521.
25. McCarville, M.B., Dickson, P.V., Gaber, W, Li, C.S., and Davidoff, A.M. (2006). Evaluation of changes in solid tumor vascularity induced by interferon-beta therapy using quantitative contrast-enhanced ultrasonography, intra-vital microscopy and histology. J Ultrasound Med, 25, S1-S118. Abstract # 200863.
26. Metzger, M.L., Howard, S.C., Hudson, M.M., Gow, K.W., Li, C.S., Krasin, M.J., Merchant, T., Kun, L., Shelso, J., Pui, C.H., Shochat, S.J., McCarville, M.B. (2006). Natural history of thyroid nodules in survivors of pediatric Hodgkin lymphoma. Pediatric Blood and Cancer, 46, 314-319.
27. McCarville, M.B., Streck, C., Li, C.S., and Davidoff, A.M. (2005). Quantitative measurement of microbubble ultrasound contrast agent ow to assess the efficacy of angiogenesis inhibitors in vivo. Pediatric Radiology, 35, S54
28. Reddick, W.E., Glass, J.O., Helton, K.J., Langston, J.W., Li, C.S., and Pui, C.H. (2005). A quantitative MR imaging assessment of leukoencephalopathy in children treated for acute lymphoblastic leukemia without irradiation. American Journal of Neuroradiology, 26, 2371-2377.
29. Zou, P., Hutchins, S., Dutzkiewicz, R., Li, C.S., and Ogg, R.J. (2005). Effects of EPI readout bandwidth on measured activation map and BOLD response in fMRI experiments. NeuroImage, 27, 15-25.
30. Ahn, H., Li, C.S., and Wang, W. (2005). Sickle cell hepatopathy: clinical presentation, treatment and outcome in pediatric and adult patients. Pediatric Blood and Cancer, 45, 184-190.
31. Hankins, J., Jeng, M., Harris, S., Li, C.S., Liu, T., and Wang, W. (2005). Chronic transfusion therapy for children with sickle cell disease and recurrent acute chest syndrome. Journal of Pediatric Hematology/Oncology, 27,158-161.
32. Jeng, M.R., Naidu, P.E., Rieman, M.D., Kelly, P., Rodriguez-Galindo, C., Li, C.S., Thornton, D., Nottage, K., and Wang, W.C. (2005) Granulocyte-Macrophage colony stimulating factor and immunosuppression in the treatment of pediatric aquired severe aplastic anemia. Pediatric Blood and Cancer, 24, 1-6.
33. Zou, P., Mulhern, R.K., Butler, R.W., Li, C.S., Langston, J.W., and Ogg, R.J. (2005). Hemodynamic responses to visual stimulation in survivors of childhood cancer. NeuroImage, 24, 61-69.
34. Williams, R., Olivi, S, Li, C.S., Storm, M., Cremer, L., Mackert, P., and Wang, W. (2004). Oral glutamine supplementation decreases resting energy expenditure in children and adolescents with sickle cell anemia. Journal of Pediatric Hematology/Oncology, 26, 619-625.
35. Rodriguez, C.A., Atkinson, R., Bitar, W., Whitney, C.G., Edwards, K.M., Mitchell, L., Li, J., Sublett, J., Li, C.S., Liu, T., Chesney, P.J., and Tuomanen, E.I. (2004). Tolerance to vancomycin in pneumococci: Detection with a molecular marker and assessment of clinical impact. Journal of Infectious Diseases, 190, 1481-1487.
36. Jeng, M.R., Adams-Graves, P., Howard, T.A., Whorton, M., Li, C.S., and Ware, R.E. (2003). Identification of hemochromatosis gene polymorphisms in chronically transfused patients with sickle cell disease. American Journal of Hematology, 74, 243-248.